I show that the size-distribution of small scattered-disk trans-Neptunian objects together with observational constraints that include the ratio of dormant to active Jupiter Family comets (JFCs), the slopes of their size-distributions, and the number of dormant nuclei in the near-Earth object (NEO) population, imply that a large percentage (95-98%) of active JFCs must physically disrupt within their dynamical lifetime. In addition, I show that the cumulative power-law slope of the scattered-disk TNO hot population between 0.2-15.4 km effective radius is only weakly dependent on the size-dependence of the disruption mechanism. Evidently, as they evolve into the inner solar system only a fraction of active Jupiter Family comet nuclei achieve dormancy while the vast majority of small nuclei (primarily with r < 2 km) break-up. The percentage disruption rate, averaged over the JFC population, appears to be comparable with that of the dynamically distinct Oort cloud and Halley type comets, suggesting that all types of comet nuclei may have similar structural characteristics even though they may have different source regions and thermal histories. The typical disruption rate of 1 km radius active nuclei is ~ 6 x 10-5 disruptions/year and the dormancy rate is ~ 3 times less.